Abaloparatide is a synthetic 34-amino-acid research peptide modeled on the biologically active N-terminal region of parathyroid hormone-related protein (PTHrP residues 1-34). It is supplied as an investigational laboratory peptide for use in PTH1R receptor pharmacology research, bone-tissue research models, and structure-activity studies on PTH-family analogs.
Laboratory research studies have positioned abaloparatide as a reference compound for examining how engineered PTHrP analogs preferentially stabilize the transient RG conformation of the parathyroid hormone type-1 receptor (PTH1R). Comparative work versus parathyroid hormone (1-34) has reported distinct cyclic AMP signaling kinetics and biased receptor engagement, providing a research model for selective PTH1R activation (Hattersley et al., 2016, Endocrinology).
Beyond receptor pharmacology, abaloparatide is investigated in cellular and animal bone-tissue research models that explore osteoblast lineage commitment, matrix-protein expression, trabecular and cortical microarchitecture, and indirect modulation of osteoclast differentiation. It is also examined in chondrocyte and cartilage research models, in spinal-tissue research, and in biomaterial-loaded delivery systems for localized bone cellular-signaling research.
The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling.
See also: Crystagen 20 mg, Cartalax 20 mg, and Epitalon.
Specifications
- Purity: 99%
- Quantity: 3 mg
- CAS Number: 247062-33-5
- Molecular Formula: C₁₇₄H₃₀₀N₅₆O₄₉
- Molecular Weight: ~3961 g/mol
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