5-Amino-1MQ (5-amino-1-methylquinolinium) is a research-grade small-molecule compound and a selective, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT). It is supplied as an investigational laboratory compound for use in metabolic-pathway research, adipose-biology research, and methyl-donor metabolism research.
Laboratory research studies have positioned 5-Amino-1MQ as a reference tool compound for examining how pharmacological NNMT inhibition reshapes intracellular nicotinamide and S-adenosyl-methionine (SAM) pools. Research models have characterised its binding to the NNMT substrate pocket, the resulting suppression of 1-methylnicotinamide (1-MNA) production, and downstream shifts in NAD⁺ salvage, lipid handling, and energy-metabolism research endpoints (Neelakantan et al., 2018, Biochemical Pharmacology).
Beyond enzyme kinetics, 5-Amino-1MQ is investigated in cellular and animal research models that explore adipocyte differentiation, lipid mobilisation, methyl-donor flux, and inflammatory-pathway signaling within metabolic tissues. Comparative metabolic-pathway research often pairs it with mitochondrial signaling tools and with ERR-targeted metabolic compounds to map overlapping energy-balance endpoints. The small-molecule scaffold, its membrane permeability, and its selectivity over related methyltransferases also make 5-Amino-1MQ a frequent subject of structure-activity research and chemical-biology studies of the NNMT pathway.
The compound is supplied as a lyophilized powder to ensure optimal stability during storage and handling.
See also: SLU-PP-332, NAD⁺, and MOTS-c 10 mg.
Specifications
- Purity: 99%
- Quantity: 10 mg
- CAS Number: 685079-15-6
- Molecular Formula: C₁₀H₁₁N₂⁺
- Molecular Weight: 159.21 g/mol
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