SS-31 (Elamipretide) is a synthetic, mitochondria-targeted tetrapeptide that selectively associates with cardiolipin within the inner mitochondrial membrane. It is classified as a cell-permeable aromatic-cationic peptide developed as a research tool for investigating mitochondrial bioenergetics, cristae architecture, and electron transport chain organization.
Through high-affinity binding to cardiolipin, SS-31 supports the structural integrity of respiratory chain supercomplexes and preserves cristae morphology under conditions of metabolic or oxidative stress. This targeted interaction has been associated with improved ATP synthesis, reduced reactive oxygen species generation, and protection of mitochondrial membrane potential in cellular and animal research models. Unlike conventional antioxidants that scavenge free radicals after they form, SS-31 is investigated for its ability to stabilize mitochondrial architecture at the source.
SS-31 is actively investigated across several research domains, including cardiac bioenergetics, neurodegeneration research, ischemia-reperfusion stress models, renal cellular-stress research, and age-related mitochondrial decline. Published studies have demonstrated that SS-31 restores mitochondrial energetics in ischemic kidney models and protects cristae structure during reperfusion (Birk et al., 2013, JASN). Its tetrapeptide structure enables rapid cellular uptake and selective localization to the inner mitochondrial membrane without disrupting membrane potential.
The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling.
See also: MOTS-c 10 mg, NAD⁺, and Glutathione 600 mg.
Specifications
- Purity: 99%
- Quantity: 10 mg
- CAS Number: 736992-21-5
- Molecular Formula: C₃₂H₄₉N₉O₅
- Molecular Weight: ~639.8 g/mol
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