MOTS-c is a mitochondria-derived peptide consisting of 16 amino acids and encoded directly by mitochondrial DNA. It is classified as a mitochondrial-encoded signaling peptide that links mitochondrial activity with nuclear gene regulation.
Through activation of AMP-activated protein kinase (AMPK) via the AICAR pathway, MOTS-c coordinates multiple metabolic pathways, including glucose utilization, lipid oxidation, and energy expenditure. Under conditions of metabolic stress, MOTS-c translocates from the mitochondria to the nucleus, where it modulates the expression of stress adaptation genes through antioxidant response elements (ARE). These effects contribute to improved metabolic flexibility, resistance to insulin dysfunction, and protection against energy-metabolism disturbances. The peptide also demonstrates antioxidant and inflammatory-pathway properties at the cellular level.
MOTS-c is actively investigated across several research domains, including insulin sensitivity and glucose homeostasis, age-related functional decline, exercise physiology and skeletal muscle metabolism, bone remodeling, and inflammatory response modulation. Published studies have demonstrated that MOTS-c administration in animal models attenuates diet-induced metabolic-adaptation shifts and supports metabolic regulation research (Lee et al., 2015, Cell Metabolism). Circulating levels of MOTS-c have been shown to decline with age, while exercise significantly upregulates its expression in skeletal muscle.
The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling.
See also: NAD⁺, SS-31 10 mg, and Epitalon.
Specifications
- Purity: 99%
- Quantity: 10 mg
- CAS Number: 1627580-64-6
- Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molecular Weight: ~2174.6 g/mol
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