Snap-8 (Acetyl Octapeptide-3) is a synthetic eight-amino-acid peptide modeled on the N-terminal sequence of the SNAP-25 protein. It is classified as a cosmetic-research peptide and is structurally extended from the earlier hexapeptide Argireline, with two additional residues that influence binding interactions in laboratory models. Snap-8 is studied as a topical-research compound in the context of skin-surface science, often alongside GHK-Cu epidermal research peptides.
At the molecular level, Snap-8 is investigated for its ability to compete with native SNAP-25 within the SNARE complex, the protein assembly responsible for vesicle docking and acetylcholine release at neuromuscular junctions. In research skin models, this competitive interaction is examined as a way to attenuate the formation of fully functional SNARE complexes, thereby influencing contraction-related signaling in cultured cell systems. The peptide is non-toxic in standard cosmetic-research assays and is positioned as an alternative-pathway compound to botulinum-toxin (BoNT/A) research models.
Snap-8 is actively studied in cosmetic-research and topical-delivery contexts, particularly in formulations designed for expression-line research, surface-texture investigation, and skin-barrier modeling. Studies on the parent hexapeptide demonstrated significant influence on expression-line measurements in controlled laboratory protocols, supporting interest in the extended Snap-8 sequence as a related research tool (Blanes-Mira et al., 2002, International Journal of Cosmetic Science). Research groups continue to evaluate Snap-8 in stability, penetration, and formulation-compatibility studies relevant to topical research models, and it is often referenced alongside the Glow blend epidermal research formulation and KPV cosmetic-adjacent inflammation research.
The peptide is supplied as a lyophilized powder to ensure optimal stability during storage and handling.
See also: GHK-Cu, Epitalon, and Cartalax 20 mg.
Specifications
- Purity: 99%
- Quantity: 10mg
- Molecular Formula: C₄₁H₇₀N₁₆O₁₆S
- Molecular Weight: 1075.2 g/mol






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