SLU-PP-332

SLU-PP-332 is a synthetic small-molecule pan-agonist of the estrogen-related receptors ERRα, ERRβ, and ERRγ, a family of orphan nuclear receptors that coordinate cellular energy programs. It is supplied as an investigational laboratory compound for use in mitochondrial-pathway research, exercise-mimetic research, and energy-metabolism research.

Laboratory research studies have positioned SLU-PP-332 as a reference tool compound for activating ERR-driven transcriptional networks that overlap with the molecular response to endurance exercise. Research models have characterised its receptor-binding profile across ERRα, ERRβ, and ERRγ, co-activator recruitment dynamics, and downstream effects on mitochondrial biogenesis, fatty-acid oxidation, and skeletal-muscle fiber composition (Billon et al., 2023, ACS Chemical Biology).

Beyond systemic energy metabolism, SLU-PP-332 is investigated in cellular and animal research models that explore cardiac mitochondrial homeostasis, oxidative muscle-fiber remodeling, and metabolic-syndrome research endpoints. The compact small-molecule scaffold and its selective ERR engagement also make SLU-PP-332 a frequent subject of structure-activity and chemical-biology research on nuclear-receptor pharmacology.

The compound is supplied as a lyophilized powder to ensure optimal stability during storage and handling.

See also: 5-Amino-1MQ 10 mg, NAD⁺, and MOTS-c 10 mg.

Specifications

• Purity: 99%
• Quantity: 500 mcg
• CAS Number: 303760-60-3
• Molecular Formula: C₁₈H₁₄N₂O₂
• Molecular Weight: ~290.3 g/mol